Humans and livestock require a broad range of nutrients to maintain a healthy diet. However, the lack of diversity in diets due to price, geography, and availability makes it difficult to create a well-rounded food supply from staple crops. Biofortification is the process of improving the nutritional quality of food and feed through management practices, plant breeding, and genetic modification. The history, types, and implications of biofortification are discussed with an emphasis on producer, livestock, and human health considerations.