This project evaluates a novel approach to managing pre-harvest fruit drop (PFD) and enhancing red coloration in ‘Honeycrisp’ apples by combining two plant growth regulators: aminoethoxyvinylglycine (AVG, marketed as ReTain) and 1-aminocyclopropane-1-carboxylic acid (ACC, marketed as Accede). Conducted over two seasons (2023–2024) in Virginia, the study compared six treatments—including ReTain, Accede, Motivate (ethephon), and their combinations—applied to mature ‘Honeycrisp’ trees. While ReTain effectively reduced fruit drop, it also suppressed color development. Conversely, Accede enhanced coloration but led to higher fruit drop. The combination of ReTain and Accede proved to balance these trade-offs, significantly reducing fruit drop while improving red color and maintaining desirable fruit quality traits. The findings offer a practical strategy to maximize both yield and marketability in ‘Honeycrisp’ apple production.